Re: L-Tryptophan

No food eaten at bedtime will guarentee a good night’s sleep. What you eat has  
some chemical connection with sleep quality, but the connection is not well  
understood. High concentrations of the amino acid tryptophan-found in  
high-protein foods such as dairy products and meat-stimulate the brain’s  
production of serotonin, a neurotransmitter, which in turn causes us to feel  
satisfied and sleepy. (Heavy consumption of sugar and other carbohydrates can  
have a similar effect.)
     Large doses of tryptophan in pill form have been shown to promote  
relaxation in some people. But the amount obtained from foods will not raise  
the tryptophan level in the blood enough to have a significant effect on sleep.  
Attempts to treat sleep disorders through diet alone have had inconclusive  
results.
     (From: University of California, Berkeley Wellness Letter April ’89)

–  
Uucp: …{gatech,ames,rutgers}!ncar!noao!asuvax!stjhmc!129!26!Carol.Galati
Internet: Carol.Gal…@f26.n129.z1.fidonet.org

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2 Responses to “Re: L-Tryptophan”

  1. admin says:

       I have experimented with taking L-Tryptophan in pill form before bedtime
    to combat occasional bouts of insomnia, usually in the dosage of 1000 – 1500
    mg.  I do fall asleep faster after taking this, but a more pronounced effect
    are the vivid dreams I have while sleeping.  A bit too vivid for my taste.  
    Sometimes I wake up feeling more mentally exhausted than when I went to sleep.

       Has anyone else experienced this from Tryp?.

    john


    john danielson
    … {seismo | harvard} ! {uwvax | cs.wisc.edu} ! astroatc! jhd

  2. admin says:

    In an article of <30 May 89 21:51:21 GMT>, bvans…@teknowledge-vaxc.ARPA  

    (Betty Van Slyke) writes:

     BV>From: bvans…@teknowledge-vaxc.ARPA (Betty Van Slyke)
     BV>Date: 30 May 89 21:51:21 GMT
     BV>Organization: Teknowledge, Inc., Palo Alto CA
     BV>Message-ID: <27…@teknowledge-vaxc.ARPA>
     BV>Newsgroups: sci.med
     BV>
     BV>In article <3…@tank.uchicago.edu> ve…@paideia.uchicago.edu (Jack L.
     BV>Vevea) writes:

     BV>
     BV>        A doctor recently suggested that I try doses of 500 to 1000 mg
     BV>of the amino acid tryptophan as a remedy for insomnia.  I’m curious
     BV>whether there is any direct evidence of such an effect; it seems a bit
     BV>unlikely, since tryptophan occurs naturally in so many foods, and is
     BV>essential in the diet at levels somewhat higher than the prescribed
     BV>dose.
     BV>Is this a legitimate suggestion that I should try (the stuff is
     BV>expensive),
     BV>or is he hoping for a placebo effect?
     BV>
     BV>        I have found that milk and cookies or soda crackers (before
     BV>        bedtime, of course) work as
     BV>        well.  Also, if you use caffeine, try cutting it out and see
     BV>        if it helps.  I am amazed at how much better I sleep since
     BV>        I stopped using caffeine.
     BV>

    There have been several published articles showing L-tryptophan to be effective  
    in decreasing sleep latency, increasing total sleep time, and improving sleep  
    quality.  There are also as many studies showing L-tryptophan to be no more  
    effective than placebo.  In the studies showing efficacy L-tryptophan tended to  
    begin to show its effects after a week or so of usage, with it having no effect  
    the first few nights.  The effective dosages where between 1 and 3 grams.  
    L-tryptophan is certainly a safe product, with only very mild side effects and  
    I think is worth a trial in chronic insomnia that will require long term  
    treatment.  For situational or transient insomnia requiring only short-term  
    treatment there are probably better agents.

    Douglas Anderson, R.Ph.

    –  
    Uucp: …{gatech,ames,rutgers}!ncar!noao!asuvax!stjhmc!147!12!Douglas.Anderson
    Internet: Douglas.Ander…@f12.n147.z1.fidonet.org

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